Defining a Therapeutic Range for Regeneration of Ischemic Myocardium via Shock Waves
(Pölzl et al., 2021. Department of Cardiac Surgery, Medical University of Innsbruck, Austria.)
Abstract
Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a therapeutic range for shock wave application for myocardial regeneration. We could demonstrate that SWT does not induce cellular damage beneath energy levels of 0.27 mJ/mm2 total flux density. Endothelial cell proliferation, angiogenic gene expression and phosphorylation of AKT and ERK are enhanced in a dose dependent manner until 0.15 mJ/mm2energy flux density. SWT induces regeneration of ischemic muscle in vivo via expression of angiogenic gene expression, enhanced neovascularization and improved limb perfusion in a dose-dependent manner. Therefore, we provide evidence for a dose-dependent induction of angiogenesis after SWT, as well as the absence of cellular damage upon SWT within the therapeutic range. These data define for the first time a therapeutic range of SWT, a promising regenerative treatment option for ischemic cardiomyopathy. 1
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Spark Wave Therapy inflicts no cellular damage at therapeutic energies
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Spark Wave Therapy induces angiogenesis and improves limb perfusion
These data define for the first time a therapeutic range of SWT. Evidence for a dose-dependent induction of
angiogenesis after SWT, as well as the absence of cellular damage upon SWT within the therapeutic range.
Reference:
- Pölzl, L. et al. Defining a therapeutic range for regeneration of ischemic myocardium via shock waves. Sci. Rep. (2021). doi:10.1038/s41598-020-79776-z